Guiding the Long Way to Broad HIV Neutralization

URN to cite this document:: urn:nbn:de:bvb:355-epub-537828
DOI to cite this document:: 10.5283/epub.53782

Peterhoff, David

; Wagner, Ralf

PDF - Accepted Version
Autorenmanuskript
(474kB)

Date of publication of this fulltext: 16 Feb 2023 12:47

Alternative links to fulltext:DOI

Details

Preview: Autorenmanuskript

Export bibliographical data

Abstract

Purpose of review It has been demonstrated that extensive virus diversification and antibody co-evolution is necessary to give rise to broadly neutralizing antibodies (bnAbs) targeting the envelope protein (Env) of HIV-1. Here we discuss recent progress of vaccine design approaches aiming on strategies to initiate and guide B cell development towards this outcome, as well as their evaluation in ...