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Quantitative structure-activity studies on 2-alkylaminoethoxy-1,4-benzodioxanes with local anesthetic activity

Bercher, H. ; Dove, Stefan ; Ramanauskas, J. J. ; Repcyte, M. A. ; Gruendling, J. ; Gruska, A. ; Grisk, A.



Abstract

The structure-activity relations of 43 2-alkylaminoethoxy derivs. of 1,4-benzodioxane were evaluated in local anesthetic tests on guinea pigs. Factor and Hansch statistical analyses were used for the detn. of contributions of 2 amino substituents and 1 addnl. alkyl or benzyl substituent.


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