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- URN zum Zitieren dieses Dokuments:
- urn:nbn:de:bvb:355-epub-539866
- DOI zum Zitieren dieses Dokuments:
- 10.5283/epub.53986
Zusammenfassung
Chimeric antigen receptors (CARs) in the canonical “second generation” format provide two signals for inducing T cell effector functions; the primary “signal-1” is provided through the TCR CD3ζ chain and the “signal-2” through a linked costimulatory domain to augment activation. While therapy with second generation CAR T cells can induce remissions of leukemia/lymphoma in a spectacular fashion, ...
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