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Abstract
Impromidine ( IMP) and arpromidine ( ARP)- derived guanidines are more potent and efficacious guinea pig ( gp) histamine H-2-receptor ( gpH(2)R) than human ( h) H2R agonists and histamine H-1- receptor ( H (1) R) antagonists with preference for hH(1)R relative to gpH(1)R. We examined N-G- acylated imidazolylpropylguani-dines ( AIPGs), which are less basic than guanidines, at hH(2)R, gpH(2)R, rat ...
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