Xie, Sheng-Xue, Ghorai, Prasanta, Ye, Qi-Zhuang, Buschauer, Armin and Seifert, Roland
(2006)
Probing Ligand-Specific Histamine H1- and H2-Receptor
Conformations with NG-Acylated Imidazolylpropylguanidines.
The Journal of Pharmacology and Experimental Therapeutics 317 (1), pp. 139-146.
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Other URL: http://jpet.aspetjournals.org/cgi/content/abstract/317/1/139
Abstract
Impromidine (IMP) and arpromidine (ARP)-derived guanidines are more potent and efficacious guinea pig (gp) histamine H2-receptor (gpH2R) than human (h) H2R agonists and histamine H1-receptor (H1R) antagonists with preference for hH1R relative to gpH1R. We examined NG-acylated imidazolylpropylguanidines (AIPGs), which are less basic than guanidines, at hH2R, gpH2R, rat H2R (rH2R), hH1R, and gpH1R ...
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| Item type: | Article | ||||
|---|---|---|---|---|---|
| Date: | 4 January 2006 | ||||
| Institutions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer) Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann, formerly Prof. Seifert) | ||||
| Projects: | GRK 760, Graduiertenkolleg Medizinische Chemie | ||||
| Identification Number: |
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| Dewey Decimal Classification: | 500 Science > 570 Life sciences 600 Technology > 610 Medical sciences Medicine | ||||
| Status: | Published | ||||
| Refereed: | Yes, this version has been refereed | ||||
| Created at the University of Regensburg: | Unknown | ||||
| Item ID: | 54 |
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