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Quantification of bulk lipid species in human platelets and their thrombin-induced release

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Heimerl, Susanne ; Höring, Marcus ; Kopczynski, Dominik ; Sigruener, Alexander ; Hart, Christina ; Burkhardt, Ralph ; Black, Anne ; Ahrends, Robert ; Liebisch, Gerhard
[img]License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 19 Apr 2023 05:27


Lipids play a central role in platelet physiology. Changes in the lipidome have already been described for basal and activated platelets. However, quantitative lipidomic data of platelet activation, including the released complex lipids, are unavailable. Here we describe an easy-to-use protocol based on flow-injection mass spectrometry for the quantitative analysis of bulk lipid species in basal ...


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