Model-based LFER parameters and QSAR of ligand-ß-adrenoceptor interactions. II. Estimation and QSAR of agonistic potency and receptor affinity in a series of ß-adrenergic phenethanolamines

Dove, Stefan und Franke, R. (1991) Model-based LFER parameters and QSAR of ligand-ß-adrenoceptor interactions. II. Estimation and QSAR of agonistic potency and receptor affinity in a series of ß-adrenergic phenethanolamines. Quantitative structure activity relationships 10 (1), S. 23-31.

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Andere URL zum Volltext: http://www3.interscience.wiley.com/journal/113323309/abstract

Zusammenfassung

Based on an equil. model of ligand-b-adrenoceptor interactions and b-adrenergic effectuation presented in a preceding paper, LFER-related biol. parameters that characterize affinity for the receptor and agonistic potency, resp., are derived for a series of 44 phenethanolamines from measured apparent dissocn. consts. KL, and intrinsic activities aAC for adenylate cyclase activation. Hansch ...

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