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Impact of Translocator Protein 18 kDa (TSPO) Deficiency on Mitochondrial Function and the Inflammatory State of Human C20 Microglia Cells

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Bader, Stefanie ; Würfel, Thea ; Jahner, Tatjana ; Nothdurfter, Caroline ; Rupprecht, Rainer ; Milenkovic, Vladimir M. ; Wetzel, Christian H.
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Date of publication of this fulltext: 03 May 2023 12:17


Abstract Microglia are the resident immune cells of the central nervous system. Upon stimulus presentation, microglia polarize from a resting to an activated state. Microglial translocator protein 18 kDa (TSPO) is considered a marker of inflammation. Here, we characterized the role of TSPO by investigating the impact of TSPO deficiency on human microglia. We used TSPO knockout (TSPO−/−) variants ...


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