Impact of Translocator Protein 18 kDa (TSPO) Deficiency on Mitochondrial Function and the Inflammatory State of Human C20 Microglia Cells

URN to cite this document:: urn:nbn:de:bvb:355-epub-541573
DOI to cite this document:: 10.5283/epub.54157

Bader, Stefanie ; Würfel, Thea

; Jahner, Tatjana ; Nothdurfter, Caroline ; Rupprecht, Rainer ; Milenkovic, Vladimir M.

; Wetzel, Christian H.

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 03 May 2023 12:17

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Abstract

Abstract Microglia are the resident immune cells of the central nervous system. Upon stimulus presentation, microglia polarize from a resting to an activated state. Microglial translocator protein 18 kDa (TSPO) is considered a marker of inflammation. Here, we characterized the role of TSPO by investigating the impact of TSPO deficiency on human microglia. We used TSPO knockout (TSPO−/−) variants ...