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Activity data decomposition - levels, methods and principles

Dove, Stefan and Franke, R. (1991) Activity data decomposition - levels, methods and principles. In: Silipo, C., (ed.) QSAR: Rational approaches in the design of bioactive compounds. Pharmacochemistry library, 16. Elsevier, Amsterdam, 37 - 40. ISBN 0-444-88839-X.

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Anal. and decompn. of biol. activity data are prerequisites to more informative QSAR results. It is often valuable to decomp. activity data of higher into such of lower complexity in order to better investigate the mechanisms of action. Three levels are discussed and illustrated with examples: systemic activity data decompn., relations of data measured in vivo and in vitro, and receptor/enzyme binding data decompn.

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Item type:Book section
Additional Information (public):Proceedings of the VIII European Symposium on Quantitative Structure-Activity Relationships, Sorrento, Italy, 9 - 13 September 1990
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
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Dewey Decimal Classification:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
600 Technology > 610 Medical sciences Medicine
Refereed:No, this version has not been refereed yet (as with preprints)
Created at the University of Regensburg:No
Item ID:5416
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