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Platz Batista da Silva, Natascha ; Scharf, Gregor ; Lürken, Lukas ; Verloh, Niklas ; Schleder, Stephan ; Stroszczynski, Christian ; Jung, Ernst Michael ; Haimerl, Michael

Different Ultrasound Shear Wave Elastography Techniques as Novel Imaging-Based Approaches for Quantitative Evaluation of Hepatic Steatosis—Preliminary Findings

Platz Batista da Silva, Natascha , Scharf, Gregor, Lürken, Lukas , Verloh, Niklas , Schleder, Stephan , Stroszczynski, Christian , Jung, Ernst Michael und Haimerl, Michael (2023) Different Ultrasound Shear Wave Elastography Techniques as Novel Imaging-Based Approaches for Quantitative Evaluation of Hepatic Steatosis—Preliminary Findings. Tomography 9 (2), S. 681-692.

Veröffentlichungsdatum dieses Volltextes: 04 Mai 2023 11:46
Artikel
DOI zum Zitieren dieses Dokuments: 10.5283/epub.54163


Zusammenfassung

Background: Modern ultrasound (US) shear-wave dispersion (SWD) and attenuation imaging (ATI) can be used to quantify changes in the viscosity and signal attenuation of the liver parenchyma, which are altered in hepatic steatosis. We aimed to evaluate modern shear-wave elastography (SWE), SWD and ATI for the assessment of hepatic steatosis. Methods: We retrospectively analyzed the US data of 15 ...

Background: Modern ultrasound (US) shear-wave dispersion (SWD) and attenuation imaging (ATI) can be used to quantify changes in the viscosity and signal attenuation of the liver parenchyma, which are altered in hepatic steatosis. We aimed to evaluate modern shear-wave elastography (SWE), SWD and ATI for the assessment of hepatic steatosis. Methods: We retrospectively analyzed the US data of 15 patients who underwent liver USs and MRIs for the evaluation of parenchymal disease/liver lesions. The USs were performed using a multifrequency convex probe (1-8 MHz). The quantitative US measurements for the SWE (m/s/kPa), the SWD (kPa-m/s/kHz) and the ATI (dB/cm/MHz) were acquired after the mean value of five regions of interest (ROIs) was calculated. The liver MRI (3T) quantification of hepatic steatosis was performed by acquiring proton density fat fraction (PDFF) mapping sequences and placing five ROIs in artifact-free areas of the PDFF scan, measuring the fat-signal fraction. We correlated the SWE, SWD and ATI measurements to the PDFF results. Results: Three patients showed mild steatosis, one showed moderate steatosis and eleven showed no steatosis in the PDFF sequences. The calculated SWE cut-off (2.5 m/s, 20.4 kPa) value identified 3/4 of patients correctly (AUC = 0.73, p > 0.05). The SWD cut-off of 18.5 m/s/kHz, which had a significant correlation (r = 0.55, p = 0.034) with the PDFF results (AUC = 0.73), identified four patients correctly (p < 0.001). The ideal ATI (AUC = 0.53 (p < 0.05)) cut-off was 0.59 dB/cm/MHz, which showed a significantly good correlation with the PDFF results (p = 0.024). Conclusion: Hepatic steatosis can be accurately detected using all the US-elastography techniques applied in this study, although the SWD and the SWE showed to be more sensitive than the PDFF.



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Details

DokumentenartArtikel
Titel eines Journals oder einer ZeitschriftTomography
Verlag:MDPI
Ort der Veröffentlichung:BASEL
Band:9
Nummer des Zeitschriftenheftes oder des Kapitels:2
Seitenbereich:S. 681-692
Datum16 März 2023
InstitutionenMedizin > Lehrstuhl für Röntgendiagnostik
Identifikationsnummer
WertTyp
10.3390/tomography9020054DOI
Stichwörter / KeywordsEFSUMB GUIDELINES; CLINICAL-USE; LIVER; RECOMMENDATIONS; DIAGNOSIS; FIBROSIS; shear-wave elastography; shear-wave dispersion; attenuation imaging; hepatic steatosis; liver MRI; PDFF
Dewey-Dezimal-Klassifikation600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin
StatusVeröffentlicht
BegutachtetJa, diese Version wurde begutachtet
An der Universität Regensburg entstandenJa
URN der UB Regensburgurn:nbn:de:bvb:355-epub-541638
Dokumenten-ID54163

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