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Platz Batista da Silva, Natascha ; Scharf, Gregor ; Lürken, Lukas ; Verloh, Niklas ; Schleder, Stephan ; Stroszczynski, Christian ; Jung, Ernst Michael ; Haimerl, Michael

Different Ultrasound Shear Wave Elastography Techniques as Novel Imaging-Based Approaches for Quantitative Evaluation of Hepatic Steatosis—Preliminary Findings

Platz Batista da Silva, Natascha , Scharf, Gregor, Lürken, Lukas , Verloh, Niklas , Schleder, Stephan , Stroszczynski, Christian , Jung, Ernst Michael and Haimerl, Michael (2023) Different Ultrasound Shear Wave Elastography Techniques as Novel Imaging-Based Approaches for Quantitative Evaluation of Hepatic Steatosis—Preliminary Findings. Tomography 9 (2), pp. 681-692.

Date of publication of this fulltext: 04 May 2023 11:46
Article
DOI to cite this document: 10.5283/epub.54163


Abstract

Background: Modern ultrasound (US) shear-wave dispersion (SWD) and attenuation imaging (ATI) can be used to quantify changes in the viscosity and signal attenuation of the liver parenchyma, which are altered in hepatic steatosis. We aimed to evaluate modern shear-wave elastography (SWE), SWD and ATI for the assessment of hepatic steatosis. Methods: We retrospectively analyzed the US data of 15 ...

Background: Modern ultrasound (US) shear-wave dispersion (SWD) and attenuation imaging (ATI) can be used to quantify changes in the viscosity and signal attenuation of the liver parenchyma, which are altered in hepatic steatosis. We aimed to evaluate modern shear-wave elastography (SWE), SWD and ATI for the assessment of hepatic steatosis. Methods: We retrospectively analyzed the US data of 15 patients who underwent liver USs and MRIs for the evaluation of parenchymal disease/liver lesions. The USs were performed using a multifrequency convex probe (1-8 MHz). The quantitative US measurements for the SWE (m/s/kPa), the SWD (kPa-m/s/kHz) and the ATI (dB/cm/MHz) were acquired after the mean value of five regions of interest (ROIs) was calculated. The liver MRI (3T) quantification of hepatic steatosis was performed by acquiring proton density fat fraction (PDFF) mapping sequences and placing five ROIs in artifact-free areas of the PDFF scan, measuring the fat-signal fraction. We correlated the SWE, SWD and ATI measurements to the PDFF results. Results: Three patients showed mild steatosis, one showed moderate steatosis and eleven showed no steatosis in the PDFF sequences. The calculated SWE cut-off (2.5 m/s, 20.4 kPa) value identified 3/4 of patients correctly (AUC = 0.73, p > 0.05). The SWD cut-off of 18.5 m/s/kHz, which had a significant correlation (r = 0.55, p = 0.034) with the PDFF results (AUC = 0.73), identified four patients correctly (p < 0.001). The ideal ATI (AUC = 0.53 (p < 0.05)) cut-off was 0.59 dB/cm/MHz, which showed a significantly good correlation with the PDFF results (p = 0.024). Conclusion: Hepatic steatosis can be accurately detected using all the US-elastography techniques applied in this study, although the SWD and the SWE showed to be more sensitive than the PDFF.



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Details

Item typeArticle
Journal or Publication TitleTomography
Publisher:MDPI
Place of Publication:BASEL
Volume:9
Number of Issue or Book Chapter:2
Page Range:pp. 681-692
Date16 March 2023
InstitutionsMedicine > Lehrstuhl für Röntgendiagnostik
Identification Number
ValueType
10.3390/tomography9020054DOI
KeywordsEFSUMB GUIDELINES; CLINICAL-USE; LIVER; RECOMMENDATIONS; DIAGNOSIS; FIBROSIS; shear-wave elastography; shear-wave dispersion; attenuation imaging; hepatic steatosis; liver MRI; PDFF
Dewey Decimal Classification600 Technology > 610 Medical sciences Medicine
StatusPublished
RefereedYes, this version has been refereed
Created at the University of RegensburgYes
URN of the UB Regensburgurn:nbn:de:bvb:355-epub-541638
Item ID54163

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