TMEM16A/F support exocytosis but do not inhibit Notch-mediated goblet cell metaplasia of BCi-NS1.1 human airway epithelium

URN to cite this document:: urn:nbn:de:bvb:355-epub-542037
DOI to cite this document:: 10.5283/epub.54203

Centeio, Raquel ; Cabrita, Inês

; Schreiber, Rainer

; Kunzelmann, Karl

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 16 May 2023 04:42

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Abstract

Cl− channels such as the Ca2+ activated Cl− channel TMEM16A and the Cl− permeable phospholipid scramblase TMEM16F may affect the intracellular Cl− concentration ([Cl−]i), which could act as an intracellular signal. Loss of airway expression of TMEM16A induced a massive expansion of the secretory cell population like goblet and club cells, causing differentiation into a secretory airway ...