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Comparative QSAR Studies in a Series of 4-(Imidazol-2'-yl)phenoxypropanolamines and Pyrid-2-yloxypropanolamines with Antihypertensive, Vasodilating and ß-Blocking Properties

Dove, Stefan ; Koch, A. ; Franke, R.



Abstract

A series of b-blocking, antihypertensive, and vasodilating (2 mechanisms, an unspecific and a b2-agonistic one) 4-(imidazol-2'-yl)-phenoxypropanolamines and pyrid-2-yl-oxopropanolamines (data from J. J. Baldwin et al.) was analyzed by a spectrum of theor. methods: factor anal., Hansch approach, conformational anal., calcn. of at. net charges and of electrostatic potentials. Factor analyses of ...

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