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Anker, Alexandra M. ; Lenhard, Jasmin ; Klein, Silvan M. ; Felthaus, Oliver ; Prantl, Lukas ; Ruewe, Marc

Standard doses of Triamcinolone do not affect fibroblast cell migration of abdominoplasty patients in-vitro1

Anker, Alexandra M. , Lenhard, Jasmin, Klein, Silvan M., Felthaus, Oliver , Prantl, Lukas und Ruewe, Marc (2022) Standard doses of Triamcinolone do not affect fibroblast cell migration of abdominoplasty patients in-vitro1. Clinical Hemorheology and Microcirculation, Prepress.

Veröffentlichungsdatum dieses Volltextes: 15 Mai 2023 09:37
Artikel
DOI zum Zitieren dieses Dokuments: 10.5283/epub.54228


Zusammenfassung

BACKGROUND:Recent studies have demonstrated that local application of corticosteroids reduces wound exudation following abdominoplasty and other reconstructive surgical procedures. On the other hand, corticosteroids might provoke wound healing disturbances due to their immunosuppressive effects. OBJECTIVE:The main objective of this study was to gain further information about the impact of the ...

BACKGROUND:Recent studies have demonstrated that local application of corticosteroids reduces wound exudation following abdominoplasty and other reconstructive surgical procedures. On the other hand, corticosteroids might provoke wound healing disturbances due to their immunosuppressive effects. OBJECTIVE:The main objective of this study was to gain further information about the impact of the corticosteroid triamcinolone on cell migration in abdominoplasty patients. METHODS:An in-vitro scratch assay wound healing model was applied to observe cell migration of fibroblasts cultured with nutrient medium containing human seroma aspirate±triamcinolone. RESULTS:There were no significant differences regarding cell migration when fibroblasts were incubated with triamcinolone + seroma containing culture medium compared to seroma containing culture medium without triamcinolone. CONCLUSIONS:The performed in-vitro study suggests that triamcinolone does not decelerate fibroblast cell migration which is considered as a surrogate of wound healing.



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Details

DokumentenartArtikel
Titel eines Journals oder einer ZeitschriftClinical Hemorheology and Microcirculation
Verlag:IOS Press
Seitenbereich:Prepress
Datum5 Dezember 2022
InstitutionenMedizin > Zentren des Universitätsklinikums Regensburg > Zentrum für Plastische-, Hand- und Wiederherstellungschirurgie
Identifikationsnummer
WertTyp
10.3233/CH-229106DOI
Stichwörter / KeywordsCell migration, fibroblasts, corticosteroids, triamcinolone, scratch assay
Dewey-Dezimal-Klassifikation600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin
StatusVeröffentlicht
BegutachtetJa, diese Version wurde begutachtet
An der Universität Regensburg entstandenJa
URN der UB Regensburgurn:nbn:de:bvb:355-epub-542285
Dokumenten-ID54228

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