Standard doses of Triamcinolone do not affect fibroblast cell migration of abdominoplasty patients in-vitro1
Anker, Alexandra M.
, Lenhard, Jasmin, Klein, Silvan M., Felthaus, Oliver
, Prantl, Lukas
und Ruewe, Marc
(2022)
Standard doses of Triamcinolone do not affect fibroblast cell migration of abdominoplasty patients in-vitro1.
Clinical Hemorheology and Microcirculation, Prepress.
Veröffentlichungsdatum dieses Volltextes: 15 Mai 2023 09:37
Artikel
DOI zum Zitieren dieses Dokuments: 10.5283/epub.54228
Zusammenfassung
BACKGROUND:Recent studies have demonstrated that local application of corticosteroids reduces wound exudation following abdominoplasty and other reconstructive surgical procedures. On the other hand, corticosteroids might provoke wound healing disturbances due to their immunosuppressive effects. OBJECTIVE:The main objective of this study was to gain further information about the impact of the ...
BACKGROUND:Recent studies have demonstrated that local application of corticosteroids reduces wound exudation following abdominoplasty and other reconstructive surgical procedures. On the other hand, corticosteroids might provoke wound healing disturbances due to their immunosuppressive effects. OBJECTIVE:The main objective of this study was to gain further information about the impact of the corticosteroid triamcinolone on cell migration in abdominoplasty patients. METHODS:An in-vitro scratch assay wound healing model was applied to observe cell migration of fibroblasts cultured with nutrient medium containing human seroma aspirate±triamcinolone. RESULTS:There were no significant differences regarding cell migration when fibroblasts were incubated with triamcinolone + seroma containing culture medium compared to seroma containing culture medium without triamcinolone. CONCLUSIONS:The performed in-vitro study suggests that triamcinolone does not decelerate fibroblast cell migration which is considered as a surrogate of wound healing.
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| Dokumentenart | Artikel | ||||
| Titel eines Journals oder einer Zeitschrift | Clinical Hemorheology and Microcirculation | ||||
| Verlag: | IOS Press | ||||
|---|---|---|---|---|---|
| Seitenbereich: | Prepress | ||||
| Datum | 5 Dezember 2022 | ||||
| Institutionen | Medizin > Zentren des Universitätsklinikums Regensburg > Zentrum für Plastische-, Hand- und Wiederherstellungschirurgie | ||||
| Identifikationsnummer |
| ||||
| Stichwörter / Keywords | Cell migration, fibroblasts, corticosteroids, triamcinolone, scratch assay | ||||
| Dewey-Dezimal-Klassifikation | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin | ||||
| Status | Veröffentlicht | ||||
| Begutachtet | Ja, diese Version wurde begutachtet | ||||
| An der Universität Regensburg entstanden | Ja | ||||
| URN der UB Regensburg | urn:nbn:de:bvb:355-epub-542285 | ||||
| Dokumenten-ID | 54228 |
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