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Computer modelling of estrogenic transcriptional activation can account for different types of dose-response curves of estrogens

Dove, Stefan ; Schönenberger, Helmut



Abstract

Estrogenic activity of diphenylethanes and -ethenes was detd. by uterine growth in immature mice and analyzed by weighed regression of logit-transformed effect on log dose values. This resulted in a range of Hill coeffs. nH from 0.3 to 2 corresponding to the mol. mechanism of estrogenic transcriptional activation. Binding of agonists (hormones, H) to estrogen receptors (ER) leads to receptor ...

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