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Intravenous injection of cyclosporin A loaded lipid nanocapsules fights inflammation and immune system activation in a mouse model of diabetic retinopathy

URN to cite this document:
urn:nbn:de:bvb:355-epub-542611
DOI to cite this document:
10.5283/epub.54261
Bohley, Marilena ; Dillinger, Andrea E. ; Braunger, Barbara M. ; Tamm, Ernst R. ; Goepferich, Achim
[img]License: Creative Commons Attribution 4.0
PDF - Published Version
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Date of publication of this fulltext: 23 May 2023 06:22

This publication is part of the DEAL contract with Springer.


Abstract

Inflammation and immune system activation are key pathologic events in the onset and escalation of diabetic retinopathy (DR). Both are driven by cytokines and complement originating from the retinal pigment epithelium (RPE). Despite the RPE’s pivotal role, there is no therapeutic tool to specifically interfere with the RPE-related pathomechanism. A therapy that addresses RPE cells and counteracts ...

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