Heterogeneity of Amino Acid Profiles of Proneural and Mesenchymal Brain-Tumor Initiating Cells

URN to cite this document:: urn:nbn:de:bvb:355-epub-542644
DOI to cite this document:: 10.5283/epub.54264

Seliger, Corinna ; Rauer, Lisa ; Wüster, Anne-Louise ; Moeckel, Sylvia ; Leidgens, Verena ; Jachnik, Birgit ; Ammer, Laura-Marie ; Heckscher, Simon ; Dettmer, Katja

; Riemenschneider, Markus J.

; Oefner, Peter J.

; Proescholdt, Martin A.

; Vollmann-Zwerenz, Arabel ; Hau, Peter

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 23 May 2023 06:57

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Abstract

Glioblastomas are highly malignant brain tumors that derive from brain-tumor-initiating cells (BTICs) and can be subdivided into several molecular subtypes. Metformin is an antidiabetic drug currently under investigation as a potential antineoplastic agent. The effects of metformin on glucose metabolism have been extensively studied, but there are only few data on amino acid metabolism. We ...