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Estrogenic activity: An example of considering effectuation models in biological data interpretation and QSAR

Dove, Stefan ; Schönenberger, Helmut Wermuth, C. G. , eds.


On a preliminary series of 1,2-dialkylated 1,2-bis(hydroxyphenyl)ethanes and -ethenes, the interrelations of affinity (pKD on estrogen receptor from calf uterus cytosol) and activity parameters (maximal estrogenic activity emax compared to estrone = 1, the Hill coeff. nH, and pD2 = log ED50) were investigated by principal component anal., leading to some first results about the structural dependence of the different steps of ligand-receptor interactions.

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