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Quantitative Structure-Activity Relationships (QSAR) in Piperidinoacetanilides for Different Biological Effects - Some General Aspects

Franke, R. ; Barth, A. ; Dove, Stefan ; Laass, W.


The title study was carried out on I (R = H, halo, Me, CF3, NO2, OMe, and OEt) and included growth inhibition of Sinapis alba seedlings and hypocotyl, Triticum aleurone amylase response, as well as anthelmintic, fungistatic and bacteriostatic activity, and inhibition of ribosomal protein synthesis. Math models for the calcn. of pI50 values (Barth, A., et al., 1977) based on hydrophobic, ...


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