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Polygenic scores for estimated glomerular filtration rate in a population of general adults and elderly – comparative results from the KORA and AugUR study

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Herold, Janina M. ; Nano, Jana ; Gorski, Mathias ; Winkler, Thomas W. ; Stanzick, Kira J. ; Zimmermann, Martina E. ; Brandl, Caroline ; Peters, Annette ; Koenig, Wolfgang ; Burkhardt, Ralph ; Gessner, André ; Heid, Iris M. ; Gieger, Christian ; Stark, Klaus J.
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Date of publication of this fulltext: 01 Jun 2023 10:36


Background Polygenic scores (PGSs) combining genetic variants found to be associated with creatinine-based estimated glomerular filtration rate (eGFRcrea) have been applied in various study populations with different age ranges. This has shown that PGS explain less eGFRcrea variance in the elderly. Our aim was to understand how differences in eGFR variance and the percentage explained by PGS ...


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