Physicochemical properties and drug action: alternative QSAR methods

Franke, R., Dove, Stefan und Gruska, A. (1994) Physicochemical properties and drug action: alternative QSAR methods. In: Kouronnakis, P. N. und Rekka, E., (eds.) Advanced Drug Design and Development, a Medicinal Chemistry Approach. Ellis Horwood Series in Pharmaceutical Technology. Ellis Horwood, London, 43 - 97. ISBN 0-13-336793-2.

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Zusammenfassung

A review with 234 refs. Biol. properties of chem. compds. depend in a very sensitive way on their chem. structure. The understanding of such dependencies in terms of so-called structure-activity relationships is one of the principal goals of medicinal chem. and at the heart of modern computer-aided drug design (CADD). CADD methods have become an indispensable tool in the search for new drugs ...

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