IRF4 downregulation improves sensitivity and endurance of CAR T cell functional capacities

URN to cite this document:: urn:nbn:de:bvb:355-epub-543744
DOI to cite this document:: 10.5283/epub.54374

Harrer, Dennis Christoph

; Bezler, Valerie ; Hartley, Jordan ; Herr, Wolfgang ; Abken, Hinrich

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 15 Jun 2023 12:12

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Abstract

Chimeric antigen receptor (CAR) modified T cells can induce complete remissions in patients with advanced hematological malignancies. Nevertheless, the efficacy is mostly transient and remains so far poor in the treatment of solid tumors. Crucial barriers to long-term CAR T cell success encompass loss of functional capacities known as “exhaustion”, among others. To extend CAR T cell ...