Scorpionfish BPI is highly active against multiple drug-resistant Pseudomonas aeruginosa isolates from people with cystic fibrosis

URN to cite this document:: urn:nbn:de:bvb:355-epub-545016
DOI to cite this document:: 10.5283/epub.54501

Holzinger, Jonas Maurice ; Toelge, Martina ; Werner, Maren ; Ederer, Katharina Ursula ; Siegmund, Heiko Ingo ; Peterhoff, David

; Blaas, Stefan Helmut ; Gisch, Nicolas ; Brochhausen, Christoph

; Gessner, André

; Bülow, Sigrid

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 20 Jul 2023 07:21

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Abstract

Chronic pulmonary infection is a hallmark of cystic fibrosis (CF) and requires continuous antibiotic treatment. In this context, Pseudomonas aeruginosa (Pa) is of special concern since colonizing strains frequently acquire multiple drug resistance (MDR). Bactericidal/permeability-increasing protein (BPI) is a neutrophil-derived, endogenous protein with high bactericidal potency against ...