A multilocus genetic risk score for obesity: Association with BMI and metabolic alterations in a cohort with severe obesity

URN to cite this document:: urn:nbn:de:bvb:355-epub-546274
DOI to cite this document:: 10.5283/epub.54627

Sag, Sabine Julia Maria

; Mueller, Stephanie ; Wallner, Stefan

; Strack, Christina ; Hubauer, Ute ; Mohr, Margareta ; Zeller, Judith

; Loew, Thomas

; Rehli, Michael

; Wimmer, Julia ; Zimmermann, Martina Erika ; Maier, Lars Siegfried

; Fischer, Marcus ; Baessler, Andrea

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 25 Aug 2023 13:57

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Abstract

Genome wide association studies have identified numerous single nucleotide polymorphisms (SNPs) associated with obesity, yet effect sizes of individual SNPs are small. Therefore, the aim of our study was to investigate whether a genetic risk score (GRS) comprising risk alleles of SNPs identified in the GIANT consortium meta-analyses shows association with body mass index (BMI) and other BMI ...