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A multilocus genetic risk score for obesity: Association with BMI and metabolic alterations in a cohort with severe obesity

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Sag, Sabine Julia Maria ; Mueller, Stephanie ; Wallner, Stefan ; Strack, Christina ; Hubauer, Ute ; Mohr, Margareta ; Zeller, Judith ; Loew, Thomas ; Rehli, Michael ; Wimmer, Julia ; Zimmermann, Martina Erika ; Maier, Lars Siegfried ; Fischer, Marcus ; Baessler, Andrea
[img]License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 25 Aug 2023 13:57


Genome wide association studies have identified numerous single nucleotide polymorphisms (SNPs) associated with obesity, yet effect sizes of individual SNPs are small. Therefore, the aim of our study was to investigate whether a genetic risk score (GRS) comprising risk alleles of SNPs identified in the GIANT consortium meta-analyses shows association with body mass index (BMI) and other BMI ...


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