Go to content
UR Home

Ibrutinib impairs IGF-1-dependent activation of intracellular Ca handling in isolated mouse ventricular myocytes

URN to cite this document:
DOI to cite this document:
Tarnowski, Daniel ; Feder, Anna-Lena ; Trum, Maximilian ; Kreitmeier, Klaus-Georg ; Stengel, Laura ; Maier, Lars S. ; Sag, Can Martin
[img]License: Creative Commons Attribution 4.0
PDF - Published Version
Date of publication of this fulltext: 29 Aug 2023 13:44


Background: The Bruton tyrosine kinase (BTK) inhibitor Ibrutinib is associated with a higher incidence of cardiotoxic side effects including heart failure (HF). Objectives: Ibrutinib is capable of inhibiting PI3K/Akt signaling in neonatal rat ventricular cardiomyocytes when stimulated with insulin-like growth factor 1 (IGF-1). We therefore hypothesized that Ibrutinib might disrupt ...


Owner only: item control page
  1. Homepage UR

University Library

Publication Server


Publishing: oa@ur.de
0941 943 -4239 or -69394

Dissertations: dissertationen@ur.de
0941 943 -3904

Research data: datahub@ur.de
0941 943 -5707

Contact persons