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Translocator protein (18kDA) (TSPO) marks mesenchymal glioblastoma cell populations characterized by elevated numbers of tumor-associated macrophages

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Weidner, Lorraine ; Lorenz, Julia ; Quach, Stefanie ; Braun, Frank K. ; Rothhammer-Hampl, Tanja ; Ammer, Laura-Marie ; Vollmann-Zwerenz, Arabel ; Bartos, Laura M. ; Dekorsy, Franziska J. ; Holzgreve, Adrien ; Kirchleitner, Sabrina V. ; Thon, Niklas ; Greve, Tobias ; Ruf, Viktoria ; Herms, Jochen ; Bader, Stefanie ; Milenkovic, Vladimir M. ; von Baumgarten, Louisa ; Menevse, Ayse N. ; Hussein, Abir ; Sax, Julian ; Wetzel, Christian H. ; Rupprecht, Rainer ; Proescholdt, Martin A. ; Schmidt, Nils O. ; Beckhove, Philipp ; Hau, Peter ; Tonn, Joerg-Christian ; Bartenstein, Peter ; Brendel, Matthias ; Albert, Nathalie L. ; Riemenschneider, Markus J.
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Date of publication of this fulltext: 19 Sep 2023 08:25


TSPO is a promising novel tracer target for positron-emission tomography (PET) imaging of brain tumors. However, due to the heterogeneity of cell populations that contribute to the TSPO-PET signal, imaging interpretation may be challenging. We therefore evaluated TSPO enrichment/expression in connection with its underlying histopathological and molecular features in gliomas. We analyzed TSPO ...


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