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Metal complexes with biologically important ligands. 62. Platinum(II) complexes of 3-(2-aminoethoxy)estrone and -estradiol
Altman, Janina, Castrillo, Thais, Beck, Wolfgang, Bernhardt, Günther and Schönenberger, Helmut (1991) Metal complexes with biologically important ligands. 62. Platinum(II) complexes of 3-(2-aminoethoxy)estrone and -estradiol. Inorganic Chemistry 30 (21), pp. 4085-4088.Date of publication of this fulltext: 05 Aug 2009 13:50
Article
DOI to cite this document: 10.5283/epub.5470
Abstract
K[PtCl3(NH3)] reacts with an equimolar amt. of 3-(2-amino-ethoxy)estrone (an) or -estradiol (ad) to give cis-[PtCl2(NH3)L] (L = an, ad). The reaction of cis-PtCl2(NH3)2 with the amino L leads to cis-[PtCl(NH3)2L]Cl (I). I (L = ad) is active against the hormone sensitive human breast cancer cell line MCF-7 and L 1210 of the mouse.
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| Item type | Article | ||||||
| Journal or Publication Title | Inorganic Chemistry | ||||||
| Publisher: | American Chemical Society | ||||||
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| Volume: | 30 | ||||||
| Number of Issue or Book Chapter: | 21 | ||||||
| Page Range: | pp. 4085-4088 | ||||||
| Date | 1991 | ||||||
| Additional Information (public) | CAN 115:196743 78-7 Inorganic Chemicals and Reactions 136392-25-1P Role: SPN (Synthetic preparation), FORM (Formation, nonpreparative), PREP (Preparation) (formation of, in prepn. of mono- and diammine analogs); 136392-21-7P; 136392-22-8P; 136392-23-9P Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), SPN (Synthetic preparation), THU (Therapeutic use), BIOL (Biological study), PREP (Preparation), USES (Uses) (prepn. and antitumor activity of); 136392-24-0P; 136458-88-3P; 136521-64-7P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. of) | ||||||
| Institutions | Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Schönenberger Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer) | ||||||
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| Keywords | Neoplasm inhibitors (platinum ammine chloro complexes with aminoethoxyestrone or -estradiol as); antitumor activity platinum chloro aminoethoxyestrone aminoethoxyestradiol; estrone aminoethoxy platinum chloro; estradiol aminoethoxy platinum chloro | ||||||
| Dewey Decimal Classification | 500 Science > 570 Life sciences 500 Science > 540 Chemistry & allied sciences | ||||||
| Status | Published | ||||||
| Refereed | Yes, this version has been refereed | ||||||
| Created at the University of Regensburg | Partially | ||||||
| URN of the UB Regensburg | urn:nbn:de:bvb:355-epub-54709 | ||||||
| Item ID | 5470 |
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