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Metal complexes with biologically important ligands. 62. Platinum(II) complexes of 3-(2-aminoethoxy)estrone and -estradiol

URN to cite this document:
urn:nbn:de:bvb:355-epub-54709
DOI to cite this document:
10.5283/epub.5470
Altman, Janina ; Castrillo, Thais ; Beck, Wolfgang ; Bernhardt, Günther ; Schönenberger, Helmut
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Date of publication of this fulltext: 05 Aug 2009 13:50


Abstract

K[PtCl3(NH3)] reacts with an equimolar amt. of 3-(2-amino-ethoxy)estrone (an) or -estradiol (ad) to give cis-[PtCl2(NH3)L] (L = an, ad). The reaction of cis-PtCl2(NH3)2 with the amino L leads to cis-[PtCl(NH3)2L]Cl (I). I (L = ad) is active against the hormone sensitive human breast cancer cell line MCF-7 and L 1210 of the mouse.


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