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| Item type: | Article | ||||
|---|---|---|---|---|---|
| Journal or Publication Title: | Archiv der Pharmazie (Weinheim, Germany) | ||||
| Volume: | 328 | ||||
| Number of Issue or Book Chapter: | 9 | ||||
| Page Range: | pp. 645-653 | ||||
| Date: | 1995 | ||||
| Additional Information (public): | CAN 124:336 1-6 Pharmacology 163168-43-2 Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), BIOL (Biological study) (prepn., stability, and antitumor activity of parenterally administrable hydrosol of [bis(fluorophenyl)ethylenediamine]dichloroplatinum(II); 125948-98-3 Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), RCT (Reactant), BIOL (Biological study), RACT (Reactant or reagent) (prepn., stability, and antitumor activity of parenterally administrable hydrosol of [bis(fluorophenyl)ethylenediamine]dichloroplatinum(II); 105990-74-7P Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), SPN (Synthetic preparation), THU (Therapeutic use), BIOL (Biological study), PREP (Preparation), USES (Uses) (prepn., stability, and antitumor activity of parenterally administrable hydrosol of [bis(fluorophenyl)ethylenediamine]dichloroplatinum(II); 7647-14-5 (Sodium chloride); 106392-12-5 (Pluronic F 68) Role: BUU (Biological use, unclassified), BIOL (Biological study), USES (Uses) (prepn., stability, and antitumor activity of parenterally administrable hydrosol of [bis(fluorophenyl)ethylenediamine]dichloroplatinum(II) | ||||
| Institutions: | Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Schönenberger Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer) | ||||
| Identification Number: |
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| Keywords: | Pharmaceutical dosage forms (hydrosols, prepn., stability, and antitumor activity of parenterally administrable hydrosol of [bis(fluorophenyl)ethylenediamine]dichloroplatinum(II); Neoplasm inhibitors (mammary gland, prepn., stability, and antitumor activity of parenterally administrable hydrosol of [bis(fluorophenyl)ethylenediamine]dichloroplatinum(II); Mammary gland (neoplasm, inhibitors, prepn., stability, and antitumor activity of parenterally administrable hydrosol of [bis(fluorophenyl)ethylenediamine]dichloroplatinum(II); platinum complex prepn stability neoplasm inhibition; fluorophenylethylenediaminedichloroplatinum complex prepn stability neoplasm inhibition | ||||
| Dewey Decimal Classification: | 500 Science > 570 Life sciences 500 Science > 540 Chemistry & allied sciences | ||||
| Status: | Published | ||||
| Refereed: | Yes, this version has been refereed | ||||
| Created at the University of Regensburg: | Partially | ||||
| Item ID: | 5477 |
Abstract
The development of a galenical formulation for poorly water sol. dichloroplatinum(II) complexes suitable for the parenteral administration in cancer chemotherapy is described. The procedure, which we elaborated for [(+-)-1,2-bis(4-fluorophenyl)ethylenediamine]dichloroplatinum(II) (rac-4F-PtCl2), is based on the reaction of a sol. diaquaplatinum(II) salt with sodium chloride in water in the ...
Abstract
The development of a galenical formulation for poorly water sol. dichloroplatinum(II) complexes suitable for the parenteral administration in cancer chemotherapy is described. The procedure, which we elaborated for [(+-)-1,2-bis(4-fluorophenyl)ethylenediamine]dichloroplatinum(II) (rac-4F-PtCl2), is based on the reaction of a sol. diaquaplatinum(II) salt with sodium chloride in water in the presence of pluronic F 68 as stabilizer and results in a sufficiently stable colloidal soln. (i.e. hydrosol). In contrast to the poorly water sol. synthetic rac-4F-PtCl2, which was ineffective towards the hormone sensitive MXt-M-3.2 breast cancer of the mouse, its hydrosol formulation proved to be highly active and was very well tolerated.
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