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Proteomic and functional mapping of cardiac NaV1.5 channel phosphorylation sites

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Lorenzini, Maxime ; Burel, Sophie ; Lesage, Adrien ; Wagner, Emily ; Charrière, Camille ; Chevillard, Pierre-Marie ; Evrard, Bérangère ; Maloney, Dan ; Ruff, Kiersten M. ; Pappu, Rohit V. ; Wagner, Stefan ; Nerbonne, Jeanne M. ; Silva, Jonathan R. ; Townsend, R. Reid ; Maier, Lars S. ; Marionneau, Céline
Date of publication of this fulltext: 05 Oct 2023 10:34


Phosphorylation of the voltage-gated Na+ (Na-V) channel Na(V)1.5 regulates cardiac excitability, yet the phosphorylation sites regulating its function and the underlying mechanisms remain largely unknown. Using a systematic, quantitative phosphoproteomic approach, we analyzed Na(V)1.5 channel complexes purified from nonfailing and failing mouse left ventricles, and we identified 42 ...


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