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NAA of platinated DNA after treatment of cancer cells with new platinum complexes

Hollstein, Michael ; Lux, Franz ; Reile, Herta ; Bernhardt, Günther ; Schönenberger, Helmut


In MCF-7 cells treated with Pt complexes, which differed from cis-(NH3)2PtCl3 by substitution of the NH3-groups with bidentate ligands, the correlation between the degree of DNA platination and the antitumor effect of complexes was examd.

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