Inhibition of ADAM17 impairs endothelial cell necroptosis and blocks metastasis

URN to cite this document:: urn:nbn:de:bvb:355-epub-547907
DOI to cite this document:: 10.5283/epub.54790

Bolik, Julia ; Krause, Freia ; Stevanovic, Marija ; Gandraß, Monja ; Thomsen, Ilka ; Schacht, Sarah-Sophie ; Rieser, Eva ; Müller, Miryam ; Schumacher, Neele ; Fritsch, Jürgen ; Wichert, Rielana ; Galun, Eithan ; Bergmann, Juri ; Röder, Christian ; Schafmayer, Clemens ; Egberts, Jan-Hendrik ; Becker-Pauly, Christoph ; Saftig, Paul ; Lucius, Ralph ; Schneider-Brachert, Wulf ; Barikbin, Roja ; Adam, Dieter ; Voss, Matthias ; Hitzl, Wolfgang ; Krüger, Achim ; Strilic, Boris ; Sagi, Irit ; Walczak, Henning ; Rose-John, Stefan ; Schmidt-Arras, Dirk

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Date of publication of this fulltext: 05 Oct 2023 11:07

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Abstract

Metastasis is the major cause of death in cancer patients. Circulating tumor cells need to migrate through the endothelial layer of blood vessels to escape the hostile circulation and establish metastases at distant organ sites. Here, we identified the membrane-bound metalloprotease ADAM17 on endothelial cells as a key driver of metastasis. We show that TNFR1-dependent tumor cell–induced ...