ATG8-dependent LMX1B-autophagy crosstalk shapes human midbrain dopaminergic neuronal resilience

URN to cite this document:: urn:nbn:de:bvb:355-epub-547914
DOI to cite this document:: 10.5283/epub.54791

Jiménez-Moreno, Natalia ; Kollareddy, Madhu ; Stathakos, Petros ; Moss, Joanna J. ; Antón, Zuriñe ; Shoemark, Deborah K. ; Sessions, Richard B. ; Witzgall, Ralph

; Caldwell, Maeve ; Lane, Jon D.

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 05 Oct 2023 13:20

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Abstract

The LIM homeodomain transcription factors LMX1A and LMX1B are essential mediators of midbrain dopaminergic neuronal (mDAN) differentiation and survival. Here we show that LMX1A and LMX1B are autophagy transcription factors that provide cellular stress protection. Their suppression dampens the autophagy response, lowers mitochondrial respiration, and elevates mitochondrial ROS, and their inducible ...