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The choice of cytostatic in hyperthermic isolated limb perfusion. Chemosensitivity testing on five human melanoma cell lines

Meyer, Thomas ; Goehl, Jonas ; Hohenberger, Werner ; Christl, Claudia ; Bernhardt, Günther ; Spruss, Thilo ; Schönenberger, Helmut



Abstract

Sensitivity of 5 human melanoma cell lines towards melphalan (L-PAM), dacarbazine (DIC), methotrexate (MTX), vinblastine (VBL), dactinomycin (DACT), doxorubicin (ADM), mitoxantrone (DHAQ), cisplatin (cDDP), and carboplatin (CDBCA) was tested by a standardized kinetic microassay. With respect to achievable plasma concns. in hyperthermic isolated limb perfusion VBL, DHAQ, ADM, DACT, and cDDP seem promising for further pharmacokinetically controlled in vivo-studies.


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