Pillwein, Konrad, Fuiko, R., Slavc, I., Czech, T., Hawliczek, G., Bernhardt, Günther, Nirnberger, Gunther and Koller, U. (1998) Hyaluronidase additional to standard chemotherapy improves outcome for children with malignant brain tumors. Cancer Letters (Shannon, Ireland) 131 (1), pp. 101-108.
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Abstract
Ex vivo expts. with vital brain tumor samples show that hyaluronidase enhances the permeation of carboplatin into tumor tissue with a matrix rich in hyaluronic acid. We achieved long-lasting second remissions for children with relapsed malignant brain tumors treated with carboplatin, etoposide and this enzyme. Thereafter, we initiated a pilot study where we added hyaluronidase to the first line ...
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| Item type: | Article | ||||
|---|---|---|---|---|---|
| Date: | 1998 | ||||
| Additional Information (public): | CAN 130:104864 1-6 Pharmacology 37326-33-3 (Hyaluronidase) Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (hyaluronidase addnl. to std. chemotherapy improves outcome for children with malignant brain tumors) | ||||
| Institutions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer) | ||||
| Identification Number: |
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| Keywords: | Antitumor agents (brain hyaluronidase addnl. to std. chemotherapy improves outcome for children with malignant brain tumors); Development (child, hyaluronidase addnl. to std. chemotherapy improves outcome for children with malignant brain tumors); Brain, neoplasms (hyaluronidase addnl. to std. chemotherapy improves outcome for children with malignant brain tumors); Brain, neoplasms (inhibitors, hyaluronidase addnl. to std. chemotherapy improves outcome for children with malignant brain tumors); child brain tumor chemotherapy hyaluronidase combination | ||||
| Dewey Decimal Classification: | 500 Science > 500 Natural sciences & mathematics 600 Technology > 610 Medical sciences Medicine | ||||
| Status: | Published | ||||
| Refereed: | Yes, this version has been refereed | ||||
| Created at the University of Regensburg: | Partially | ||||
| Item ID: | 5484 |
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