Pillwein, Konrad, Fuiko, R., Slavc, I., Czech, T., Hawliczek, G., Bernhardt, Günther, Nirnberger, Gunther und Koller, U. (1998) Hyaluronidase additional to standard chemotherapy improves outcome for children with malignant brain tumors. Cancer Letters (Shannon, Ireland) 131 (1), S. 101-108.
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Zusammenfassung
Ex vivo expts. with vital brain tumor samples show that hyaluronidase enhances the permeation of carboplatin into tumor tissue with a matrix rich in hyaluronic acid. We achieved long-lasting second remissions for children with relapsed malignant brain tumors treated with carboplatin, etoposide and this enzyme. Thereafter, we initiated a pilot study where we added hyaluronidase to the first line ...
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| Dokumentenart: | Artikel | ||||
|---|---|---|---|---|---|
| Datum: | 1998 | ||||
| Zusätzliche Informationen (Öffentlich): | CAN 130:104864 1-6 Pharmacology 37326-33-3 (Hyaluronidase) Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (hyaluronidase addnl. to std. chemotherapy improves outcome for children with malignant brain tumors) | ||||
| Institutionen: | Chemie und Pharmazie > Institut für Pharmazie > Lehrstuhl Pharmazeutische / Medizinische Chemie II (Prof. Buschauer) | ||||
| Identifikationsnummer: |
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| Stichwörter / Keywords: | Antitumor agents (brain hyaluronidase addnl. to std. chemotherapy improves outcome for children with malignant brain tumors); Development (child, hyaluronidase addnl. to std. chemotherapy improves outcome for children with malignant brain tumors); Brain, neoplasms (hyaluronidase addnl. to std. chemotherapy improves outcome for children with malignant brain tumors); Brain, neoplasms (inhibitors, hyaluronidase addnl. to std. chemotherapy improves outcome for children with malignant brain tumors); child brain tumor chemotherapy hyaluronidase combination | ||||
| Dewey-Dezimal-Klassifikation: | 500 Naturwissenschaften und Mathematik > 500 Naturwissenschaften 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin | ||||
| Status: | Veröffentlicht | ||||
| Begutachtet: | Ja, diese Version wurde begutachtet | ||||
| An der Universität Regensburg entstanden: | Zum Teil | ||||
| Eingebracht am: | 15 Jan 2009 15:40 | ||||
| Zuletzt geändert: | 24 Mai 2018 10:11 | ||||
| Dokumenten-ID: | 5484 |
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