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Hyaluronidase additional to standard chemotherapy improves outcome for children with malignant brain tumors

Pillwein, Konrad ; Fuiko, R. ; Slavc, I. ; Czech, T. ; Hawliczek, G. ; Bernhardt, Günther ; Nirnberger, Gunther ; Koller, U.



Abstract

Ex vivo expts. with vital brain tumor samples show that hyaluronidase enhances the permeation of carboplatin into tumor tissue with a matrix rich in hyaluronic acid. We achieved long-lasting second remissions for children with relapsed malignant brain tumors treated with carboplatin, etoposide and this enzyme. Thereafter, we initiated a pilot study where we added hyaluronidase to the first line ...

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