Spruss, Thilo und Bernhardt, Günther (1996) Chemosensitivity of malignant melanoma models: long-term complete remission after regional hyaluronidase/vinblastine therapy. In: Arnold, Wolfgang, (ed.) Immunodeficient Animals: Models for Cancer Research. Contributions to Oncology, 51. , S. 145-150.
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Zusammenfassung
Peritumoral s.c. injection of hyaluronidase (100,000 IU/kg), followed 4 later by s.c. injection of vinblastine (0.3 mg/kg, a dose which by itself had no antitumor activity), was given to nude mice bearing various human malignant melanomas. Seven such treatments (1/wk) were performed from day 22 to day 64. On day 78, histol. examns. revealed complete cure (absence of tumor cells). At the dose ...
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| Dokumentenart: | Buchkapitel | ||||
|---|---|---|---|---|---|
| Datum: | 1996 | ||||
| Zusätzliche Informationen (Öffentlich): | CAN 125:75390 1-4 Pharmacology 865-21-4 (Vinblastine) Role: BAC (Biological activity or effector, except adverse), BPR (Biological process), BSU (Biological study, unclassified), BIOL (Biological study), PROC (Process) (chemosensitivity of malignant melanoma to regional hyaluronidase/vinblastine therapy); 9001-54-1 (Hyaluronidase) Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), BIOL (Biological study) (chemosensitivity of malignant melanoma to regional hyaluronidase/vinblastine therapy) | ||||
| Institutionen: | Chemie und Pharmazie > Institut für Pharmazie > Lehrstuhl Pharmazeutische / Medizinische Chemie II (Prof. Buschauer) | ||||
| Identifikationsnummer: |
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| Stichwörter / Keywords: | Drug interactions (chemosensitivity of malignant melanoma to regional hyaluronidase/vinblastine therapy); Neoplasm inhibitors (melanoma, chemosensitivity of malignant melanoma to regional hyaluronidase/vinblastine therapy); vinblastine hyaluronidase interaction melanoma inhibition; antitumor vinblastine hyaluronidase interaction | ||||
| Dewey-Dezimal-Klassifikation: | 500 Naturwissenschaften und Mathematik > 570 Biowissenschaften, Biologie 500 Naturwissenschaften und Mathematik > 500 Naturwissenschaften | ||||
| Status: | Veröffentlicht | ||||
| Begutachtet: | Ja, diese Version wurde begutachtet | ||||
| An der Universität Regensburg entstanden: | Ja | ||||
| Eingebracht am: | 15 Jan 2009 15:27 | ||||
| Zuletzt geändert: | 08 Mrz 2017 08:20 | ||||
| Dokumenten-ID: | 5485 |
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