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Chemosensitivity of malignant melanoma models: long-term complete remission after regional hyaluronidase/vinblastine therapy

Spruss, Thilo ; Bernhardt, Günther


Peritumoral s.c. injection of hyaluronidase (100,000 IU/kg), followed 4 later by s.c. injection of vinblastine (0.3 mg/kg, a dose which by itself had no antitumor activity), was given to nude mice bearing various human malignant melanomas. Seven such treatments (1/wk) were performed from day 22 to day 64. On day 78, histol. examns. revealed complete cure (absence of tumor cells). At the dose ...


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