Spruss, Thilo and Bernhardt, Günther (1996) Chemosensitivity of malignant melanoma models: long-term complete remission after regional hyaluronidase/vinblastine therapy. In: Arnold, Wolfgang, (ed.) Immunodeficient Animals: Models for Cancer Research. Contributions to Oncology, 51. , pp. 145-150.
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Abstract
Peritumoral s.c. injection of hyaluronidase (100,000 IU/kg), followed 4 later by s.c. injection of vinblastine (0.3 mg/kg, a dose which by itself had no antitumor activity), was given to nude mice bearing various human malignant melanomas. Seven such treatments (1/wk) were performed from day 22 to day 64. On day 78, histol. examns. revealed complete cure (absence of tumor cells). At the dose ...
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| Item type: | Book section | ||||
|---|---|---|---|---|---|
| Date: | 1996 | ||||
| Additional Information (public): | CAN 125:75390 1-4 Pharmacology 865-21-4 (Vinblastine) Role: BAC (Biological activity or effector, except adverse), BPR (Biological process), BSU (Biological study, unclassified), BIOL (Biological study), PROC (Process) (chemosensitivity of malignant melanoma to regional hyaluronidase/vinblastine therapy); 9001-54-1 (Hyaluronidase) Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), BIOL (Biological study) (chemosensitivity of malignant melanoma to regional hyaluronidase/vinblastine therapy) | ||||
| Institutions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer) | ||||
| Identification Number: |
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| Keywords: | Drug interactions (chemosensitivity of malignant melanoma to regional hyaluronidase/vinblastine therapy); Neoplasm inhibitors (melanoma, chemosensitivity of malignant melanoma to regional hyaluronidase/vinblastine therapy); vinblastine hyaluronidase interaction melanoma inhibition; antitumor vinblastine hyaluronidase interaction | ||||
| Dewey Decimal Classification: | 500 Science > 570 Life sciences 500 Science > 500 Natural sciences & mathematics | ||||
| Status: | Published | ||||
| Refereed: | Yes, this version has been refereed | ||||
| Created at the University of Regensburg: | Yes | ||||
| Item ID: | 5485 |
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