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Identification of DUSP4/6 overexpression as a potential rheostat to NRAS-induced hepatocarcinogenesis

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Klemm, Sophie ; Evert, Katja ; Utpatel, Kirsten ; Muggli, Alexandra ; Simile, Maria M. ; Chen, Xin ; Evert, Matthias ; Calvisi, Diego F. ; Scheiter, Alexander
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Date of publication of this fulltext: 17 Nov 2023 08:57


Background Upregulation of the mitogen-activated protein kinase (MAPK) cascade is common in hepatocellular carcinoma (HCC). Neuroblastoma RAS viral oncogene homolog (NRAS) is mutated in a small percentage of HCC and is hitherto considered insufficient for hepatocarcinogenesis. We aimed to characterize the process of N-Ras-dependent carcinogenesis in the liver and to identify potential ...


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