Chronic Active Epstein-Barr Virus (EBV) Infection Controlled by Allogeneic Stem Cell Transplantation and EBV-Specific T Cells

URN to cite this document:: urn:nbn:de:bvb:355-epub-550325
DOI to cite this document:: 10.5283/epub.55032

Meedt, Elisabeth ; Weber, Daniela ; Bonifacius, Agnes

; Eiz-Vesper, Britta ; Maecker-Kolhoff, Britta ; Delecluse, Susanne ; Delecluse, Henri-Jacques ; Lorenz, Myriam ; Schwarz, Klaus ; Meedt, Stefan T. ; Braess, Jan ; Herr, Wolfgang ; Holler, Ernst ; Edinger, Matthias ; Wolff, Daniel

Date of publication of this fulltext: 17 Nov 2023 14:08

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Abstract

We report sustained remission of chronic active Epstein-Barr virus (EBV) infection in a 27-year-old female patient treated with third-party EBV-specific T cells followed by allogeneic hematopoietic stem cell transplantation (HSCT). The viremia cleared after administration of anti-T-lymphocyte globulin for graft-versus-host disease (GvHD) prophylaxis. Subsequent expansion of EBV-infected host T cells was controlled by transfusion of donor-derived EBV-specific T cells.

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