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Potency and durability of T and B cell immune responses after homologous and heterologous vector delivery of a trimer-stabilized, membrane-displayed HIV-1 clade ConC Env protein

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Perdiguero, Beatriz ; Hauser, Alexandra ; Gómez, Carmen Elena ; Peterhoff, David ; Sideris, Elefthéria ; Sorzano, Carlos Óscar S. ; Wilmschen, Sarah ; Schaber, Marion ; Stengel, Laura ; Asbach, Benedikt ; Ding, Song ; Von Laer, Dorothee ; Levy, Yves ; Pantaleo, Giuseppe ; Kimpel, Janine ; Esteban, Mariano ; Wagner, Ralf
[img]License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 30 Nov 2023 10:56


Introduction: The generation of an HIV-1 vaccine able to induce long-lasting protective immunity remains a main challenge. Here, we aimed to modify next-generation soluble, prefusion-stabilized, close-to-native, glycan-engineered clade C gp140 envelope (Env) trimers (sC23v4 KIKO and ConCv5 KIKO) for optimal display on the cell surface following homologous or heterologous vector ...


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