The Important Role of Protein Kinases in the p53 Sestrin Signaling Pathway

URN to cite this document:: urn:nbn:de:bvb:355-epub-550512
DOI to cite this document:: 10.5283/epub.55051

Gülow, Karsten ; Tümen, Deniz ; Kunst, Claudia

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 30 Nov 2023 12:52

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Abstract

p53, a crucial tumor suppressor and transcription factor, plays a central role in the maintenance of genomic stability and the orchestration of cellular responses such as apoptosis, cell cycle arrest, and DNA repair in the face of various stresses. Sestrins, a group of evolutionarily conserved proteins, serve as pivotal mediators connecting p53 to kinase-regulated anti-stress responses, with ...