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The Important Role of Protein Kinases in the p53 Sestrin Signaling Pathway

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Gülow, Karsten ; Tümen, Deniz ; Kunst, Claudia
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Date of publication of this fulltext: 30 Nov 2023 12:52


p53, a crucial tumor suppressor and transcription factor, plays a central role in the maintenance of genomic stability and the orchestration of cellular responses such as apoptosis, cell cycle arrest, and DNA repair in the face of various stresses. Sestrins, a group of evolutionarily conserved proteins, serve as pivotal mediators connecting p53 to kinase-regulated anti-stress responses, with ...


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