Abstract
Cross-coupling reactions are a vital aspect of modern organic synthesis, enabling the creation of necessary C–C or C–(het)atom bonds. Although C(sp2)–C and C(sp2)–N cross-coupling reactions have received significant attention, recent advancements have highlighted the significance of C(sp2)–S cross-coupling reactions. These reactions lead to the synthesis of valuable compounds, including ...
Abstract
Cross-coupling reactions are a vital aspect of modern organic synthesis, enabling the creation of necessary C–C or C–(het)atom bonds. Although C(sp2)–C and C(sp2)–N cross-coupling reactions have received significant attention, recent advancements have highlighted the significance of C(sp2)–S cross-coupling reactions. These reactions lead to the synthesis of valuable compounds, including pharmaceuticals and materials. However, as with other bond-forming reactions, challenges arise when selecting the optimal pre-catalysts, solvents, bases, and additives for a successful cross-coupling reaction. In a recent report, we introduced Adaptive Dynamic Homogeneous Catalysis (AD-HoC) as an efficient method for C(sp2)–S cross-coupling reactions. This method operates without the need for any additives, relying solely on essential parameters. In this report, we discuss the use of mesoporous graphitic carbon nitride (mpg-CN) as an all-organic heterogeneous photocatalyst in such transformations. The use of mpg-CN as a catalyst enables the recovery of the photocatalyst and facilitates the sequential execution of multiple cross-coupling reactions with consistent yields of the desired products using a simple setup. This approach is a significant advancement in the field, both in terms of operational simplicity and environmental impact, which is a trait that we all envision for sustainability.
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