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Peroxisome proliferator-activated receptorα/γ agonist pioglitazone for rescuing relapsed or refractory neoplasias by unlocking phenotypic plasticity

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Harrer, Dennis Christoph ; Lüke, Florian ; Pukrop, Tobias ; Ghibelli, Lina ; Gerner, Christopher ; Reichle, Albrecht ; Heudobler, Daniel
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Date of publication of this fulltext: 26 Jan 2024 17:10


A series of seven clinical trials on relapsed or refractory (r/r) metastatic neoplasias followed the question: Are networks of ligand-receptor cross-talks that support tumor-specific cancer hallmarks, druggable with tumor tissue editing approaches therapeutically exploiting tumor plasticity? Differential recombinations of pioglitazone, a dual peroxisome-proliferator activated receptorα/γ ...


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