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Mitochondrial and Cellular Function in Fibroblasts, Induced Neurons, and Astrocytes Derived from Case Study Patients: Insights into Major Depression as a Mitochondria-Associated Disease

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Cardon, Iseline ; Grobecker, Sonja ; Kücükoktay, Selin ; Bader, Stefanie ; Jahner, Tatjana ; Nothdurfter, Caroline ; Koschitzki, Kevin ; Berneburg, Mark ; Weber, Bernhard H. F. ; Stöhr, Heidi ; Höring, Marcus ; Liebisch, Gerhard ; Braun, Frank K. ; Rothammer-Hampl, Tanja ; Riemenschneider, Markus J. ; Rupprecht, Rainer ; Milenkovic, Vladimir M. ; Wetzel, Christian H.
[img]License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 29 Jan 2024 13:57


The link between mitochondria and major depressive disorder (MDD) is increasingly evident, underscored both by mitochondria’s involvement in many mechanisms identified in depression and the high prevalence of MDD in individuals with mitochondrial disorders. Mitochondrial functions and energy metabolism are increasingly considered to be involved in MDD’s pathogenesis. This study focused on ...


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