Both coiling and clipping induce the time-dependent release of endogenous neuropeptide Y into serum

URN to cite this document:: urn:nbn:de:bvb:355-epub-555967
DOI to cite this document:: 10.5283/epub.55596

Bründl, Elisabeth

; Proescholdt, Martin A. ; Schödel, Petra ; Rosengarth, Katharina ; Störr, Eva-Maria ; Bele, Sylvia

; Kieninger, Martin

; Malsy, Manuela ; Schmidt, Nils Ole

; Schebesch, Karl-Michael

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 05 Mar 2024 12:01

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Abstract

Abstract

Background:
The vaso- and psychoactive endogenous Neuropeptide
Y (NPY) has repeatedly been shown to be excessively released after
subarachnoid hemorrhage and in numerous psychiatric disorders. NPY is
stored in sympathetic perivascular nerve fibers around the major cerebral
arteries. This prospective study was designed to analyze the impact of
microsurgical and endovascular manipulation of the cerebral vasculature
versus cranio- and durotomy alone on the serum levels of NPY.
Methods:
58 patients (drop-out n = 3; m:f = 26:29; mean age
52.0 ± 14.1 years) were prospectively enrolled. The vascular group
underwent repair for unruptured intracranial aneurysms (UIA) of the
anterior circulation [endovascular aneurysm occlusion (EV) n = 13;
microsurgical clipping (MS) n = 17]; in the non-vascular group, 14
patients received microsurgical resection of a small-sized convexity
meningioma (CM), and 11 patients with surgically treated degenerative
lumbar spine disease (LD) served as control. Plasma was drawn (1)
before treatment (t0), (2) periprocedurally (t1), (3) 6 h postprocedurally
(t2), (4) 72 h postprocedurally (t3), and (5) at the 6-week follow-up (FU;
t4) to determine the NPY levels via competitive enzyme immunoassay in
duplicate serum samples. We statistically evaluated differences between
groups by calculating one-way ANOVA and for changes along the time
points using repeated measure ANOVA.
Results:
Except for time point t0, the serum concentrations of NPY
ranged significantly higher in the vascular than in the non-vascular
group (p < 0.001), with a slight decrease in both vascular subgroups 6 h
postprocedurally, followed by a gradual increase above baseline levels
until FU. At t3, the EV subgroup showed significantly higher NPY levels
(mean ± standard deviation) than the MS subgroup (0.569 ± 0.198 ng/
mL vs. 0.415 ± 0.192 ng/mL, p = 0.0217). The highest NPY concentrations
were measured in the EV subgroup at t1, t3, and t4, reaching a climax at
FU (0.551 ± 0.304 ng/mL).
Conclusion:
Our study reveals a first insight into the short-term
dynamics of the serum levels of endogenous NPY in neurosurgical and
endovascular procedures, respectively: Direct manipulation within but also next to the major cerebral arteries induces an excessive release of NPY into the serum. Our findings raise the interesting question of the potential capacity of NPY in modulating the psycho-behavioral outcome of neurovascular patients

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