Schwarz, Edward M. 
; McLaren, Alex C. ; Sculco, Thomas P. ; Brause, Barry ; Bostrom, Mathias ; Kates, Stephen L. ; Parvizi, Javad ; Alt, Volker ; Arnold, William V. ; Carli, Alberto ; Chen, Antonia F. ; Choe, Hyonmin ; Coraça‐Huber, Débora C. ; Cross, Michael ; Ghert, Michelle ; Hickok, Noreen ; Jennings, Jessica Amber ; Joshi, Manjari ; Metsemakers, Willem‐Jan ; Ninomiya, Mark ; Nishitani, Kohei ; Oh, Irvin ; Padgett, Douglas ; Ricciardi, Benjamin ; Saeed, Kordo ; Sendi, Parham ; Springer, Bryan ; Stoodley, Paul ; Wenke, Joseph C.
; McLaren, Alex C. ; Sculco, Thomas P. ; Brause, Barry ; Bostrom, Mathias ; Kates, Stephen L. ; Parvizi, Javad ; Alt, Volker ; Arnold, William V. ; Carli, Alberto ; Chen, Antonia F. ; Choe, Hyonmin ; Coraça‐Huber, Débora C. ; Cross, Michael ; Ghert, Michelle ; Hickok, Noreen ; Jennings, Jessica Amber ; Joshi, Manjari ; Metsemakers, Willem‐Jan ; Ninomiya, Mark ; Nishitani, Kohei ; Oh, Irvin ; Padgett, Douglas ; Ricciardi, Benjamin ; Saeed, Kordo ; Sendi, Parham ; Springer, Bryan ; Stoodley, Paul ; Wenke, Joseph C. 
Abstract
Antibiotic-loaded bone cement (ALBC) is broadly used to treat orthopaedic infections based on the rationale that high-dose local delivery is essential to eradicate biofilm-associated bacteria. However, ALBC formulations are empirically based on drug susceptibility from routine laboratory testing, which is known to have limited clinical relevance for biofilms. There are also dosing concerns with ...
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