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The predictive power of CD3+ T cell infiltration of oral squamous cell tumors is limited to non-diabetic patients

Spanier, Gerrit ; Ugele, Ines ; Nieberle, Felix ; Symeou, Luisa ; Schmidhofer, Sandra ; Brand, Almut ; Meier, Johannes ; Spoerl, Steffen ; Krupar, Rosemarie ; Rümmele, Petra ; Siska, Peter ; Renner, Kathrin ; Peter, Katrin ; Gerken, Michael ; Beckhove, Philipp ; Reichert, Torsten E. ; Kreutz, Marina ; Singer, Katrin



Abstract

Diabetes mellitus type II (DM) and immune cell infiltration determine patient outcome in many tumor entities. Here we studied a possible link between the metabolic and immune cell status of OSCC patients. Glucose transporter (GLUT) 1 mRNA expression was elevated in all tumor samples, whereas other glycolytic markers such as lactate dehydrogenase (LDH) A or monocarboxylate transporter (MCT) 1 were ...

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