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Loss of PKD1 and PKD2 share common effects on intracellular Ca2+ signaling

Cabrita, Ines ; Talbi, Khaoula ; Kunzelmann, Karl ; Schreiber, Rainer


In polycystic kidney disease (PKD) multiple bilateral renal cysts gradually enlarge causing a decline in renal function. Transepithelial chloride secretion through cystic fibrosis transmembrane conductance regulator (CFTR) and TMEM16A (anoctamin 1) drive cyst enlargement. We demonstrated recently that a loss of PKD1 increases expression and function of TMEM16A in murine kidneys and in mouse M1 ...


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