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HEMA-induced oxidative stress inhibits NF-κB nuclear translocation and TNF release from LTA- and LPS-stimulated immunocompetent cells

Schweikl, Helmut ; Birke, Margaritha ; Gallorini, Marialucia ; Petzel, Christine ; Bolay, Carola ; Waha, Claudia ; Hiller, Karl-Anton ; Buchalla, Wolfgang


Objective: The release of inflammatory cytokines from antigen-stimulated cells of the Resin monomer immune system is inhibited by resin monomers such as 2-hydroxyethyl methacrylate HEMA (HEMA). Although the formation of oxidative stress in cells exposed to HEMA is firmly estab- Oxidative stress lished, the mechanism behind the inhibited cytokine secretion is only partly known. The Cytokine ...


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