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CX3CL1 Overexpression Prevents the Formation of Lung Metastases in Trastuzumab-Treated MDA-MB-453-Based Humanized Tumor Mice (HTM)

Wege, Anja Kathrin ; Dreyer, Tobias F. ; Teoman, Attila ; Ortmann, Olaf ; Brockhoff, Gero ; Bronger, Holger



Abstract

Simple Summary In about 15-18% of breast cancers the HER2 gene is amplified, which allows an anti-HER2 treatment. However, about 50% of HER2-positive patients experience de novo or acquired resistance to the antibody-based therapy with trastuzumab. Therefore, the identification of predictive markers for therapy success and novel combination strategies is needed. Here we explored the impact of ...

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