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Assessment of concentration and penetration depth of cisplatin in human lung tissue after decortication and hyperthermic exposure

Larisch, Christopher ; Markowiak, Till ; Loch, Elena ; Großer, Christian ; Bednarski, Patrick J. ; Mueller, Karolina ; Hofmann, Hans-Stefan ; Ried, Michael


Background: Hyperthermic perfusion of the pleural cavity with cisplatin after pleurectomy/decortication is an additional therapeutic option to reduce local relapse of malignant pleural tumours. Although there are data on the clinical effect, only little is known about the local impact on human lung tissue by cisplatin. The objective of this experimental study is to evaluate both the concentration ...


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