Chimäre Antigenrezeptoren (CAR) – universelle Werkzeuge in der zellulären Immuntherapie - Publikationsserver der Universität Regensburg

Holzinger, A. ; Abken, H.

Alternative Links zum Volltext:DOI Verlag

Bibliographische Daten exportieren

Zusammenfassung

Background The observation that tumor-infiltrating lymphocytes (TIL) after ex vivo amplification can control tumors in the long term led to the concept of redirecting patients & apos; cytolytic T-cells by a receptor with defined specificity against the tumor. Objectives Development of a recombinant receptor-signal molecule (chimeric antigen receptor, CAR) to increase selectivity and enhance ...