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Novel TGFβ Inhibitors Ameliorate Oral Squamous Cell Carcinoma Progression and Improve the Antitumor Immune Response of Anti–PD-L1 Immunotherapy

Ludwig, Nils ; Wieteska, Łukasz ; Hinck, Cynthia S. ; Yerneni, Saigopalakrishna S. ; Azambuja, Juliana H. ; Bauer, Richard J. ; Reichert, Torsten E. ; Hinck, Andrew P. ; Whiteside, Theresa L.



Abstract

TGF beta is a key regulator of oral squamous cell carcinoma (OSCC) progression, and its potential role as a therapeutic target has been investigated with a limited success. This study evaluates two novel TGF beta inhibitors as mono or combinatorial therapy with anti-PD-L1 antibodies (alpha-PD-L1 Ab) in a murine OSCC model. Immunocompetent C57BL/6 mice bearing malignant oral lesions induced by ...

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