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A novel ocular function for decorin in the aqueous humor outflow

Schneider, Magdalena ; Pawlak, Ramona ; Weber, Gregor R. ; Dillinger, Andrea E. ; Kuespert, Sabrina ; Iozzo, Renato V. ; Quigley, Harry A. ; Ohlmann, Andreas ; Tamm, Ernst R. ; Fuchshofer, Rudolf



Abstract

Primary open-angle glaucoma, a neurodegenerative disorder characterized by degeneration of optic nerve axons, is a frequent cause of vision loss and blindness worldwide. Several randomized multicenter studies have identified intraocular pressure as the major risk factor for its development, caused by an increased outflow resistance to the aqueous humor within the trabecular meshwork. However, the ...

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